Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor)

Yasuka Toda, Tomoya Nakagita, Takashi Hayakawa, Shinji Okada, Masataka Narukawa, Hiroo Imai, Yoshiro Ishimaru, Takumi Misaka

研究成果: Article査読

61 被引用数 (Scopus)

抄録

Background: T1R1/T1R3 exhibits species-dependent differences in ligand specificity. Results: The ligand specificity is dependent on a combination of amino acid selectivity at the orthosteric site and receptor activity modulation at the non-orthosteric site. Conclusion: The molecular mechanism underlying the amino acid recognition of T1R1/T1R3 has been elucidated. Significance: This study provides new insights into the molecular mechanisms of the L-Glu-specific response in human T1R1/T1R3.

本文言語English
ページ(範囲)36863-36877
ページ数15
ジャーナルJournal of Biological Chemistry
288
52
DOI
出版ステータスPublished - 27 12月 2013

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