Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species

Yuta Mochimaru, Jun Negishi, Syo Murakami, Shiori Musha, Koichi Sato, Fumikazu Okajima, Hideaki Tomura

研究成果: Article

6 被引用数 (Scopus)

抄録

Human, mouse, and zebrafish ovarian cancer G protein--coupled receptors (OGR1s) are activated by both metals and extracellular protons. In the present study, we examined whether pig, rat, chicken, and Xenopus OGR1 homologs could sense and be activated by protons and metals. We found that all homologs stimulated serum response element (SRE)-driven promoter activities when they are stimulated by protons. On the other hand, metals differentially activated the homologs. The results using chimeric receptors of human and zebrafish OGR1s indicate that the specificity of the metal-induced activation lies in the extracellular region. These results suggest that protons are an evolutionally conserved agonist of OGR1. However, the types of metals that activated the receptor differed among the homologs.

本文言語English
ページ(範囲)109-114
ページ数6
ジャーナルZoological Science
35
2
DOI
出版ステータスPublished - 1 4 2018

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