Cytotoxicity and suppression of immunoglobulin production against human namalwa cells caused by oxidized cholesterol

Kyoichi Osada, Takehiro Kodama, Noritaka Matsuo, Koji Yamada, Michihiro Sugano

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The effects of oxidized cholesterols on proliferation and IgM production of human lymphoblastoid Namalwa cells were examined. An oxidized cholesterol mixture, in contrast to cholesterol, was a potent cytotoxin to Namalwa cells. Among oxidized cholesterols examined, 25-hydroxycholesterol was the most cytotoxic. However, no oxidized cholesterol examined suppressed IgM production, although cholestanetriol and 7-ketocholesterol did suppress it. Thus, oxidized cholesterols are cytotoxic to lymphocytes, while the influence on the immunoglobulin production may be marginal.

本文言語English
ページ(範囲)1362-1364
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
60
8
DOI
出版ステータスPublished - 1月 1996

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