Multi-core panel is widely used in raised floor structure. However, it has the disadvantage of heavy weight. In this paper, the authors try to reduce the weight of the raised floor structure by replacing multi-core panel with truss core panel, which is a well-known lightweight structure using origami engineering. The intension and stiffness of truss core panel for raised floor model are investigated. The multi-core panel and the truss core panel are compared by running impact test and load test. Response Surface Method (RSM) is used to optimize the shape of truss core panel. The explicit FEM software LS-DYNA is used to solve impact-load analysis. The results show that 23.69% weight reduction is achieved for exiting multi-core panel of raised floor by using truss core panel.