Zinc-catalyzed direct cyanation of indoles and pyrroles: Nitromethane as a source of a cyano group

Yuta Nagase, Tetsuya Sugiyama, Shota Nomiyama, Kyohei Yonekura, Teruhisa Tsutimoto

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With nitromethane and diphenylsilane (Ph2SiH2), zinc triflate behaves as a Lewis acid catalyst for the cyanation of nitrogen-containing heteroarenes such as indoles and pyrroles. This is the first realization of the Lewis acid-catalyzed direct cyanation of a C(aryl)-H bond with no CN group-containing cyanating agent.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalAdvanced Synthesis and Catalysis
Issue number2-3
Publication statusPublished - 10 Feb 2014


  • Heteroarenes
  • Heterocycles
  • Lewis acids
  • Nitriles; zinc

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