The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition

Yori Ozaki-Masuzawa, Hiroki Kosaka, Rino Abiru, Yumiko Toda, Kota Kawabata, Mari Nagata, Shohei Hara, Morichika Konishi, Nobuyuki Itoh, Takashi Hosono, Asako Takenaka, Taiichiro Seki

Research output: Contribution to journalArticlepeer-review

Abstract

Protein malnutrition promotes hepatic lipid accumulation in growing animals. In these animals, fibroblast growth factor 21 (FGF21) rapidly increases in the liver and circulation and plays a protective role in hepatic lipid accumulation. To investigate the mechanism by which FGF21 protects against liver lipid accumulation under protein malnutrition, we determined whether upregulated FGF21 promotes the thermogenesis or secretion of very-low-density lipoprotein (VLDL)-triacylglycerol (TAG). The results showed that protein malnutrition decreased VLDL-TAG secretion, but the upregulation of FGF21 did not oppose this effect. In addition, protein malnutrition increased expression of the thermogenic gene uncoupling protein 1 in inguinal white adipose and brown adipose tissue in an FGF21-dependent manner. However, surgically removing inguinal white adipose tissue did not affect liver triglyceride levels in protein-malnourished mice. These data suggest that FGF21 stimulates thermogenesis under protein malnutrition, but this is not the causative factor underlying the protective role of FGF21 against liver lipid accumulation.

Original languageEnglish
Pages (from-to)1104-1113
Number of pages10
JournalBioscience, Biotechnology, and Biochemistry
Volume85
Issue number5
DOIs
Publication statusPublished - 24 Apr 2021

Keywords

  • FGF21
  • fibroblast growth factor 21
  • liver lipid accumulation
  • low-protein diet
  • protein malnutrition

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