Synthesis of aminoacylated ergosterols: A new lipid component of fungi

Daisuke Yokokawa, Shunsuke Tatematsu, Ryoka Takagi, Yusuke Saga, Hervé Roy, Frédéric Fischer, Hubert D. Becker, Tetsuo Kushiro

Research output: Contribution to journalArticlepeer-review

Abstract

Aminoacylated ergosterol such as 1-ergosteryl aspartate (Erg-Asp) is a new lipid component recently discovered in fungi. In order to study physiological functions of this novel sterol derivative and to develop potential antifungal agents, we established the method to synthesize aminoacylated ergosterol derivatives. Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.

Original languageEnglish
Article number108823
JournalSteroids
Volume169
DOIs
Publication statusPublished - May 2021

Keywords

  • 1-Ergosteryl aspartate
  • Aminoacylated sterol
  • Ergosterol
  • Fungi

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