Staphylococcus epidermidis is involved in a mechanism for female reproduction in mice

Chihiro Ono, Manabu Yoshida, Natsuko Kawano, Kenji Miyado, Akihiro Umezawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Both external and internal surfaces of organs (e.g., skin, mouth, gut, and intestine) are covered with bacteria, which often contribute to physiological events in host animals. Despite externally opened organs, the presence of bacteria in the mammalian female reproductive tract is uncertain. Here we assessed this problem using wild-type strains of mice, C57BL/6N and ICR. We first demonstrated that bacterial colonies were formed from the oviductal fluid in the C57BL/6N mice with birth experience ("parous"), but not in the mice without birth experience ("non-parous"). Sequence analysis of 16S ribosomal RNA (rRNA) revealed that Staphylococcus epidermidis existed in the oviductal fluid of the parous mice, confirmed by immunohistochemical analysis. Furthermore, extinction of bacterial population with intraperitoneal injection of antibiotics, penicillin G and streptomycin, disturbed the regularly implanted pattern of embryos in ICR mice. Our results indicate that symbiotic S.epidermidis plays a role in interaction between embryo and uterus upon implantation in mice.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalRegenerative Therapy
Publication statusPublished - 1 Jun 2015


  • Female reproduction
  • Staphylococcus aureus
  • Staphylococcus epidermidis
  • Symbiosis


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