Soft contact-lens sensor for monitoring tear sugar as novel wearable device of body sensor network

M. K. Chu, K. Mitsubayashi, K. Miyajima, T. Arakawa, Hiroyuki Kudo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A soft contact-lens amperometric glucose sensor as novel wearable device of body sensor network was fabricated and tested. Also, the sensor was utilized to tear glucose monitoring. The sensor was constructed by immobilizing GOD onto a flexible oxygen electrode, which was fabricated using “Soft-MEMS” techniques onto a functional polymer membrane. In purpose of bioinstrumentation, adhesive agents were not used for constructing the flexible biosensor. Linear relationship between glucose concentration and output current was obtained in a range of 0.039 – 0.537 mmol/l. Current dependences on pH and temperature were also evaluated. The current was largest at pH 7.0 and the current increased when temperature increased. This indicates that the output current depends on enzyme activity. Based on the basic characteristics investigation, the glucose sensor was applied to measurement of glucose in tear fluids on an eye site of a Japan white rabbit. The change of tear glucose level induced by oral-administration of glucose was monitored as a current change of the sensor attached on the eye site. In this investigation, the tear glucose level varied from 0.2 mmol/l to 0.5 mmol/l. Although there was a delay of several tens of minutes towards blood sugar level, it is considered to be possible that noninvasive continuous glucose monitoring can be realized using the flexible biosensor.

Original languageEnglish
Title of host publicationProceedings
Subtitle of host publicationDMS 2011 - 17th International Conference on Distributed Multimedia Systems
PublisherKnowledge Systems Institute Graduate School
Pages54-57
Number of pages4
ISBN (Electronic)1891706306
Publication statusPublished - 1 Jan 2011
Event17th International Conference on Distributed Multimedia Systems, DMS 2011 - Florence, Italy
Duration: 18 Aug 201120 Aug 2011

Publication series

NameProceedings: DMS 2011 - 17th International Conference on Distributed Multimedia Systems

Conference

Conference17th International Conference on Distributed Multimedia Systems, DMS 2011
CountryItaly
CityFlorence
Period18/08/1120/08/11

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Keywords

  • Body sensor network
  • Diabetes control
  • Tear sugar
  • Wearable sensor

Cite this

Chu, M. K., Mitsubayashi, K., Miyajima, K., Arakawa, T., & Kudo, H. (2011). Soft contact-lens sensor for monitoring tear sugar as novel wearable device of body sensor network. In Proceedings: DMS 2011 - 17th International Conference on Distributed Multimedia Systems (pp. 54-57). (Proceedings: DMS 2011 - 17th International Conference on Distributed Multimedia Systems). Knowledge Systems Institute Graduate School.