Protons Differentially Activate TDAG8 Homologs from Various Species

Shiori Musha, Suminori Nagayama, Syo Murakami, Ryotaro Kojima, Masahito Deai, Koichi Sato, Fumikazu Okajima, Hiroki Ueharu, Hideaki Tomura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Mammalian T cell death-associated gene 8 (TDAG8)s are activated by extracellular protons. In the present study, we examined whether the TDAG8 homologs of other species are activated by protons as they are in mammals. We found that Xenopus TDAG8 also stimulated cAMP response element (CRE)-driven promoter activities reflecting the activation of G s /cAMP signaling pathways when they are stimulated by protons. On the other hand, the activities of chicken and zebrafish TDAG8s are hardly affected by protons. Results using chimeric receptors of human and zebrafish TDAG8s indicate that the specificity of the proton-induced activation lies in the extracellular region. These results suggest that protons are not an evolutionarily conserved agonist of TDAG8.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalZoological Science
Issue number2
Publication statusPublished - 1 Jan 2019


  • chimeric receptor
  • CRE-promoter
  • N-terminal region
  • proton
  • T cell death-associated gene 8

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