Optical evaluation of microvascular function at early and chronic stages of diabetes

Shotaro Sasaki, Mikie Nakabayashi, Yumie Ono, Masashi Ichinose

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated blood flow response for reactive hyperemia test in type1 diabetic and control rats using diffuse correlation spectroscopy (DCS). The baseline blood flow, peak amplitude and time to peak blood flow responses after releasing from ischemia were significantly decreased after induction of hyperglycemic state in diabetic rats. Furthermore, the baseline blood flow and the peak amplitude were significantly decreased from 1st week to 10th week in diabetic rats, suggesting the progress of vascular dysfunction caused by sustained glycemic stress. This research showed a potential of DCS to diagnose vascular function in diabetes that was altered by acute and chronic hyperglycemic stress.

Original languageEnglish
Title of host publicationBiophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables
EditorsBabak Shadgan, Amir H. Gandjbakhche
PublisherSPIE
ISBN (Electronic)9781510632370
DOIs
Publication statusPublished - 2020
EventBiophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables 2020 - San Francisco, United States
Duration: 1 Feb 20202 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11237
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables 2020
CountryUnited States
CitySan Francisco
Period1/02/202/02/20

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  • Cite this

    Sasaki, S., Nakabayashi, M., Ono, Y., & Ichinose, M. (2020). Optical evaluation of microvascular function at early and chronic stages of diabetes. In B. Shadgan, & A. H. Gandjbakhche (Eds.), Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables [112370R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11237). SPIE. https://doi.org/10.1117/12.2545267