On enzymatic pH oscillations in CSTR with outlet regulator

Takao Ohmori, Weifang Yu, Takuji Yamamoto, Akira Endo, Masaru Nakaiwa, Takashi Amemiya, Tomohiko Yamaguchi

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The possibility of enzymatic pH oscillations is investigated for a CSTR with an outlet regulator. A linear stability analysis shows that no oscillation is possible in a CSTR without the regulator, using a proton-producing pH-dependent enzymatic reaction. However, self-sustained oscillations are found to occur in a CSTR, where the discharge of substrate is regulated at the outlet. The regions of oscillations in the parameter space are determined using a hydrolysis of N-α-benzoyl-l-arginine ethyl ester with papain. It is found that the region is quite large only when the substrate concentration in the outflow is kept at zero.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalChemical Physics Letters
Issue number1-3
Publication statusPublished - 17 May 2005

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    Ohmori, T., Yu, W., Yamamoto, T., Endo, A., Nakaiwa, M., Amemiya, T., & Yamaguchi, T. (2005). On enzymatic pH oscillations in CSTR with outlet regulator. Chemical Physics Letters, 407(1-3), 48-52. https://doi.org/10.1016/j.cplett.2005.03.060