N-isopropylacrylamide-based copolymer for encapsulation of pancreatic islets

S. Shimizu, S. Kubota, H. Moriya, T. Watanabe, K. Hasegawa, M. Nagaya, S. Yamaguchi

Research output: Contribution to conferencePaper

Abstract

The thermoreversible gelation polymer (TGP) composed of poly(N-isopropylacrylamide-co-acryoxysuccinimide-co-n-butylmethacrylate) and diamino poly(ethylane glycol) was used to make microencapsulated islets and was examined in vitro. The microencapsulated islets were found to be active from day-1. the groups displayed a similar pattern of insulin secretion. The maximum insulin concentration was seen days 5 to 7, with no statistically significant difference. The morphological and functional stability of the method for islet microencapsulation can be satisfactory applied to transplantation for diabetic animals.

Original languageEnglish
Number of pages1
Publication statusPublished - 1 Dec 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: 29 May 19962 Jun 1996

Conference

ConferenceProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period29/05/962/06/96

Cite this

Shimizu, S., Kubota, S., Moriya, H., Watanabe, T., Hasegawa, K., Nagaya, M., & Yamaguchi, S. (1996). N-isopropylacrylamide-based copolymer for encapsulation of pancreatic islets. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .