Investigation of composition effect on PLGA/hydroxyapatite hybrid materials (II) function of FL. -crystallinity and mechanical properties

Miki Hayashi, Yuko Takeoka, Mamoru Aizawa, Masahiro Rikukawa, Kohei Sanui

Research output: Contribution to conferencePaper

Abstract

Hydroxyapatite (Ca10(PO4)6(OH) 2; HAp) has been used as a biomaterial due to its similarity to bone mineral in structure, composition, and its good biocompatibility to human tissue. Recently, much attention has been focused on the combination of HAp composites with biodegradable polymers to overcome the problem of poor mechanical properties of HAp. In this study, we tried to fabricate poly(lactic-co-glycolic acid) (PLGA)/HAp by the in-situ polymerization in porous HAp with lipase as a catalyst. The effect of molar ratio of L-lactide in PLGA (FL) on their mechanical properties was examined. The maximum bending strength and the fracture toughness of the hybrids were 91.1 MPa and 1.30 MPa·m1/2 at FL = 0 %, respectively. The mechanical properties of composites increased with decreasing the FL of PLGA, indicating that the properties of the hybrids could be controlled by the crystallinity of the polymer in HAp.

Original languageEnglish
Number of pages1
Publication statusPublished - 19 Oct 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 24 May 200626 May 2006

Conference

Conference55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period24/05/0626/05/06

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Keywords

  • Artificial bone
  • Enzymatic polymerization
  • Hydroxy apatite
  • PLGA

Cite this

Hayashi, M., Takeoka, Y., Aizawa, M., Rikukawa, M., & Sanui, K. (2006). Investigation of composition effect on PLGA/hydroxyapatite hybrid materials (II) function of FL. -crystallinity and mechanical properties. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.