Inhibition of Cholesterol Absorption by Oxidized Cholesterol in Rats

Kyoichi Osada, Eiji Sasaki, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The effects on cholesterol absorption of oxidized cholesterols were studied in lymph-cannulated rats. When a single emulsified lipid meal containing a tracer amount of [14C]cholesterol with either 50 mg cholesterol or 50 mg oxidized cholesterol mixture was administered intragastrically, the lymphatic absorption of cholesterol for 24 h was 33.1 ±6.3 and 21.7 ±8.6%, respectively. Moreover, oxidized cholesterols also inhibited the absorption of triolein (85.9 ±3.2% and 59.5 ± 18.8%). The observation may be of use since the ingestion of oxidized cholesterols tends to be increasing.

Original languageEnglish
Pages (from-to)782-783
Number of pages2
JournalBioscience, Biotechnology, and Biochemistry
Issue number4
Publication statusPublished - 1994


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