Identification of a novel blue pigment as a melanoidin intermediate in the D-xylose-glycine reaction system

Shigeyuki Sasaki, Yoshinobu Shirahashi, Kazuyuki Nishiyama, Hirohito Watanabe, Fumitaka Hayase

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Some blue pigments were formed in the D-xylose (1 M)-glycine (0.1 M) reaction system. A novel blue pigment, designated as Blue-M2 (blue Maillard intermediate-2), was identified as 5-[1,4-dicarboxymethyl-5-(2,3- dihydroxypropyl)-1,4-dihydropyrrolo[3,2-b]pyrrole-2-ylmethylene]-1, 4-dicarboxymethyl-2-{5-[N-carboxymethyl(2,3,4-trihydroxytetrahydrofuran-2-yl) methylamino]-2-hydroxymethyl-4-(1,2,3-trihydroxypropyl)-tetrahydrofuran-3-yl}-4, 5-dihydropyrrolo-[3,2-b]pyrrole-1-ium. Blue-M2 is presumed to have been generated by the reaction between Blue-M1, which was identified as the major blue pigment in a previous paper (Hayase et al., Biosci. Biotechnol. Biochem., 63, 1512-1514 (1999)), and di-D-xyluloseglycine. Blue pigments are important Maillard reaction intermediates through the formation of melanoidins.

Original languageEnglish
Pages (from-to)2529-2531
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - 6 Nov 2006


  • Blue pigment
  • Di-D-xyluloseglycine
  • Maillard reaction
  • Melanoidin
  • Pyrrolopyrrole aldehyde

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