@inbook{c04195ab2eb842c09465cda8b5336a53,

title = "Generalized-ensemble algorithms for protein folding simulations",

abstract = "Conventional simulations of complex systems in the canonical ensemble suffer from the quasi-ergodicity problem. A simulation in generalized ensemble overcomes this difficulty by performing a random walk in potential energy space and other parameter space. From only one simulation run, one can obtain canonical-ensemble averages of physical quantities as functions of temperature by the single-histogram and/or multiple-histogram reweighting techniques. In this article, we review the generalized-ensemble algorithms. Three well-known methods, namely multicanonical algorithm, simulated tempering, and replica-exchange method, are described first. Both Monte Carlo and molecular dynamics versions of the algorithms are given. We then present further extensions of the above three methods.",

author = "Yuji Sugita and Ayori Mitsutake and Yuko Okamoto",

note = "Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

doi = "10.1007/978-3-540-74029-2_14",

language = "English",

isbn = "9783540740254",

series = "Lecture Notes in Physics",

pages = "369--407",

editor = "Wolfhard Janke",

booktitle = "Rugged Free Energy Landscapes",

}