Fabrication of biodegradable β-tricalcium phosphate/poly(L-lactic acid) hybrids and their in vitro biocompatibility

Yusuke Shigemitsu, Nami Sugiyama, Kazuya Oribe, Masahiro Rikukawa, Mamoru Aizawa

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Hybrids of β-tricalcium phosphate (β-TCP) and poly(L-lactic acid) (PLLA) have been fabricated, which can be expected to be a novel filler for biodegradable bone grafting. Firstly, porous β-TCP ceramics have been made of calcium-phosphate fiber synthesized by homogeneous precipitation method. Then, the hybrids have been fabricated by introducing PLLA having highmolecular-weight into the open pores of the porous β-TCP ceramics. The mechanical property was enhanced, for example, by annealing the hybrids at 140°C for 24 h; the bending strength was 17.1 MPa, which was about 1.5 times that of the porous β-TCP ceramics. The biocompatibility has been examined using osteoblastic cell, MC3T3-E1, and found to be comparable to that of pure β-TCP ceramics.

Original languageEnglish
Pages (from-to)1181-1187
Number of pages7
JournalJournal of the Ceramic Society of Japan
Issue number1384
Publication statusPublished - Dec 2010


  • Biocompatibility
  • Ceramics-polymer hybrids
  • Poly(L-lactic acid)
  • Porous ceramics
  • β-tricalcium phosphate

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