Exclusive synthesis of β-alkylpyrroles under indium catalysis: Carbonyl compounds as sources of alkyl groups

Teruhisa Tsuchimoto, Motohiro Igarashi, Kazuki Aoki

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

No longer difficult: Just mixing readily available carbonyl compounds, pyr-roles, and nucleophiles with an indium catalyst was found to give β-alkylpyr-roles in a regiospecific manner. Removal of benzyl (Bn) and cumyl groups from the nitrogen atoms of the products enables access to nitrogen-unsubstituted β-alkylpyrroles (see scheme).

Original languageEnglish
Pages (from-to)8975-8979
Number of pages5
JournalChemistry - A European Journal
Volume16
Issue number30
DOIs
Publication statusPublished - 19 Aug 2010

Keywords

  • Aldehydes
  • C-C activation
  • Indium
  • Ketones
  • Nucleophilic substitution

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