Entorhinal-hippocampal interactions revealed by real-time imaging

Toshio Iijima, Menno P. Witter, Michinori Ichikawa, Takashi Tominaga, Riichi Kajiwara, Gen Matsumoto

Research output: Contribution to journalArticlepeer-review

199 Citations (Scopus)


The entorhinal cortex provides the major cortical input to the hippocampus, and both structures have been implicated in memory processes. The dynamics of neuronal circuits in the entorhinal-hippocampal system were studied in slices by optical imaging with high spatial and temporal resolution. Reverberation of neural activity was detected in the entorhinal cortex and was more prominent when the inhibition due to γ-aminobutyric acid was slightly suppressed. Neural activity was transferred in a frequency-dependent way from the entorhinal cortex to the hippocampus. The entorhinal neuronal circuit could contribute to memory processes by holding information and selectively gating the entry of information into the hippocampus.

Original languageEnglish
Pages (from-to)1176-1179
Number of pages4
Issue number5265
Publication statusPublished - 24 May 1996


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