Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet

Kazuki Yui, Ayane Kiyofuji, Kyoichi Osada

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19 Citations (Scopus)

Abstract

Xanthohumol is the major prenylated flavonoid of female inflorescences of the hop plant (Humulus lupulus L.) and is a hydrophobic favonoid. We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. Dietary xanthohumol-rich hop extract signifcantly lowered the body weight gain of these rats compared to rats fed a high-fat diet without the extract. The increase of body weight, liver weight, and triacylglycerol levels in the plasma and liver of the rats fed a high-fat diet was ameliorated by dietary xanthohumol-rich hop extract. Dietary xanthohumol-rich hop extract tended to reduce hepatic fatty acid synthesis through the reduction of hepatic SREBP1c mRNA expression in the rats fed a high-fat diet. The excreted of triacylglycerol into feces also was promoted by dietary xanthohumol-rich hop extract. Plasma adiponectin levels in the rats fed a high-fat diet also tended to be elevated by dietary xanthohumol-rich hop extract. Thus, xanthohumol-rich hop extract may inhibit the increase of body weight, liver weight, and triacylglycerol in the plasma and liver induced by feeding high-fat diet through the regulation of hepatic fatty acid metabolism and inhibition of intestinal fat absorption. Therefore, xanthohumol-rich hop extract may exert preventive function on the increase of body weight and tissue triacylglycerol levels by overnutrition.

Original languageEnglish
Pages (from-to)159-168
Number of pages10
JournalJournal of oleo science
Volume63
Issue number2
DOIs
Publication statusPublished - 10 Feb 2014

Keywords

  • Fatty acid metabolism
  • Hop
  • Obesity
  • Rat
  • Xanthohumol

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