Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats

Shohei Kobayashi, Natsuko Kawano, Kenji Miyado, Ryo Ohta, Takahiro Akimoto, Taichi Hatakeyama, Maiko Kawaguchi

Research output: Contribution to journalComment/debate

Abstract

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm motion and concentration in adult male Wistar–Imamichi rats. Thirty-five days after the final administration, sperm parameters were evaluated by computer-assisted sperm analysis. Results showed that sperm swimming progression and vigor and sperm concentration in TDCIPP-treated rats were unexpectedly higher than those in control rats. TDCIPP did not significantly affect the percentage of motile sperms or sperm swimming pattern. These results contribute to the understanding of the biological effects of TDCIPP.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalJournal of Veterinary Medical Science
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • 3-dichloro-2-propyl) phosphate
  • Anti-androgenic substance
  • Computer-assisted sperm analysis
  • Flame retardant
  • Sperm
  • Tris(1

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