@article{e6ae7b959c65429bb82efea11909baf1,
title = "Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats",
abstract = "Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm motion and concentration in adult male Wistar–Imamichi rats. Thirty-five days after the final administration, sperm parameters were evaluated by computer-assisted sperm analysis. Results showed that sperm swimming progression and vigor and sperm concentration in TDCIPP-treated rats were unexpectedly higher than those in control rats. TDCIPP did not significantly affect the percentage of motile sperms or sperm swimming pattern. These results contribute to the understanding of the biological effects of TDCIPP.",
keywords = "3-dichloro-2-propyl) phosphate, Anti-androgenic substance, Computer-assisted sperm analysis, Flame retardant, Sperm, Tris(1",
author = "Shohei Kobayashi and Natsuko Kawano and Kenji Miyado and Ryo Ohta and Takahiro Akimoto and Taichi Hatakeyama and Maiko Kawaguchi",
note = "Funding Information: We appreciate the members of the Laboratory of Animal Behavior and Environmental Science, especially A. Onuma, for the assistance with the experiments. This study was supported in part by the Environment Research and Technology Development Fund (JPMEERF18S11703) from the Environmental Restoration and Conservation Agency of Japan. Funding Information: ACKNOWLEDGMENTS. We appreciate the members of the Laboratory of Animal Behavior and Environmental Science, especially A. Onuma, for the assistance with the experiments. This study was supported in part by the Environment Research and Technology Development Fund (JPMEERF18S11703) from the Environmental Restoration and Conservation Agency of Japan. Publisher Copyright: {\textcopyright} 2022 The Japanese Society of Veterinary Science.",
year = "2022",
month = jan,
doi = "10.1292/jvms.21-0046",
language = "English",
volume = "84",
pages = "153--156",
journal = "Journal of Veterinary Medical Science",
issn = "0916-7250",
publisher = "Japanese Society of Veterinary Science",
number = "1",
}