Determination of glyceraldehyde formed in glucose degradation and glycation

Teruyuki Usui, Miku Yoshino, Hirohito Watanabe, Fumitaka Hayase

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Glyceraldehyde (GLA) was determined in glucose degradation and glycation. GLA was detected as a decahydroacridine-1,8-dione derivative on reversed phase HPLC using cyclohexane-1,3-dione derivatizing reagent. The glucose-derived GLA level was higher than the glycation-derived GLA level, because GLA was converted to intermediates and advanced glycation end products (AGE) in glycation. GLA was also generated from 3-deoxyglucosone and glucosone as intermediates of glucose degradation and glycation. This study suggests that glyceraldehyde is generated by hyperglycemia in diabetes, and that it is also formed in medicines such as peritoneal dialysis solution.

Original languageEnglish
Pages (from-to)2162-2168
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Issue number9
Publication statusPublished - 21 Nov 2007


  • 1,3-cyclohexanedione
  • Glucose degradation
  • Glycation
  • Glyceraldehyde
  • Maillard reaction

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