Cytotoxicity and suppression of immunoglobulin production against human namalwa cells caused by oxidized cholesterol

Kyoichi Osada, Takehiro Kodama, Noritaka Matsuo, Koji Yamada, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The effects of oxidized cholesterols on proliferation and IgM production of human lymphoblastoid Namalwa cells were examined. An oxidized cholesterol mixture, in contrast to cholesterol, was a potent cytotoxin to Namalwa cells. Among oxidized cholesterols examined, 25-hydroxycholesterol was the most cytotoxic. However, no oxidized cholesterol examined suppressed IgM production, although cholestanetriol and 7-ketocholesterol did suppress it. Thus, oxidized cholesterols are cytotoxic to lymphocytes, while the influence on the immunoglobulin production may be marginal.

Original languageEnglish
Pages (from-to)1362-1364
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume60
Issue number8
DOIs
Publication statusPublished - Jan 1996

Keywords

  • Cholesterol
  • Cytotoxicity
  • Immunoglobulin
  • Lymphocytes
  • Oxidized cholesterol

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