Biosynthesis of baccharis oxide, a triterpene with a 3, 10-oxide bridge in the A-ring

Masaaki Shibuya, Aya Sagara, Ai Saitoh, Tetsuo Kushiro, Yutaka Ebizuka

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

(Chemical Equation Presented) A new oxidosqualene cyclase (OSC) cDNA was cloned from the roots of Stevia rebaudlana. Functional expression in yeast and spectral analyses of the products established that the obtained OSC yields baccharis oxide as the major product. This is the first identification of an OSC yielding baccharis oxide. This result clearly demonstrated that baccharis oxide, a baccharane triterpene with a unique 3, 10-oxide bridge in the A-ring, is a direct product from oxidosqualene by an OSC.

Original languageEnglish
Pages (from-to)5071-5074
Number of pages4
JournalOrganic Letters
Volume10
Issue number21
DOIs
Publication statusPublished - 1 Dec 2008

Fingerprint

Dive into the research topics of 'Biosynthesis of baccharis oxide, a triterpene with a 3, 10-oxide bridge in the A-ring'. Together they form a unique fingerprint.

Cite this