A Strategy for Suppressing Macrophage-mediated Rejection in Xenotransplantation

Akira Maeda, Pei Chi Lo, Rieko Sakai, Yuki Noguchi, Tasuku Kodama, Tomohisa Yoneyama, Chiyoshi Toyama, Han Tang Wang, Emilio Esquivel, Patmika Jiaravuthisan, Thuy Vy Choi, Chihiro Takakura, Hiroshi Eguchi, Yuko Tazuke, Masahito Watanabe, Hiroshi Nagashima, Hiroomi Okuyama, Shuji Miyagawa

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Although xenografts are one of the most attractive strategies for overcoming the shortage of organ donors, cellular rejection by macrophages is a substantial impediment to this procedure. It is well known that macrophages mediate robust immune responses in xenografts. Macrophages also express various inhibitory receptors that regulate their immunological function. Recent studies have shown that the overexpression of inhibitory ligands on porcine target cells results in the phosphorylation of tyrosine residues on intracellular immunoreceptor tyrosine-based inhibitory motifs on macrophages, leading to the suppression of xenogenic rejection by macrophages. It has also been reported that myeloid-derived suppressor cells, a heterogeneous population of immature myeloid cells, suppress not only NK and cytotoxic T lymphocyte cytotoxicity but also macrophage-mediated cytotoxicity. This review is focused on the recent findings regarding strategies for inhibiting xenogenic rejection by macrophages.

Original languageEnglish
Pages (from-to)675-681
Number of pages7
JournalTransplantation
Volume104
Issue number4
DOIs
Publication statusPublished - 1 Apr 2020

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