A flexible transcutaneous oxygen sensor using polymer membranes

Hiroyuki Kudo, Shigehito Iguchi, Takua Yamada, Tatsuya Kawase, Hirokazu Saito, Kimio Otsuka, Kohji Mitsubayashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A wearable and flexible oxygen sensor for transcutaneous blood gas monitoring was fabricated and tested. The sensor has a laminar film-like structure, which was fabricated by pouching KCl electrolyte solution by both non-permeable (metal weldable) sheet and gas-permeable membrane with Pt- and Ag/AgCl-electrodes patterned using microfabrication process. The electrolyte solution was fixed only by heat-sealing the edges of the weldable membranes without any chemical adhesives. The wearable oxygen sensor (thickness: 84 μm) was applied to the electrochemical measurement with a constant potential of -600 mV vs. Ag/ AgCl, thus obtaining the calibration range to dissolved oxygen (DO) from 0.0to 7.0 mg/l with a correlation coefficient of 0.998 and the quick response time (53.4 s to 90% of a steady-state current), which operate similarly to a commercially available oxygen electrode. The sensor was also utilized to transcutaneous oxygen monitoring for healthy human subject. The sensing region of the wearable oxygen sensor was attached onto the forearm-skin surface of the subject inhaling various concentrations of oxygen. As a result of physiological application, the output current was varied from -6.2 μA to -7.8μA within 2 min when the concentration of inhaling oxygen was changed from atmospheric air to 60% oxygen. Thus, the transcutaneous oxygen was successfully monitored without any inconveniences such as skin inflammation, etc.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalBiomedical Microdevices
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Feb 2007

Keywords

  • Amperometric sensor
  • Bioinstrumentation
  • Flexible
  • Oxygen sensor
  • Transcutaneous monitoring

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  • Cite this

    Kudo, H., Iguchi, S., Yamada, T., Kawase, T., Saito, H., Otsuka, K., & Mitsubayashi, K. (2007). A flexible transcutaneous oxygen sensor using polymer membranes. Biomedical Microdevices, 9(1), 1-6. https://doi.org/10.1007/s10544-006-9000-z