A drug-injection system with chemo-mechanical energy conversion for active feedback control of glucose concentration in a blood

Takahiro Arakawa, Ryodai Kato, Munkhjargal Munkhjargal, Daishi Takahashi, Hiroyuki Kudo, Kohji Mitsubayashi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel autonomous drug release system based on chemo-mechanical energy was fabricated and tested. The system consists of two integrated units: decompression unit so-called organic engine and drug release unit. Glucose oxidase (GOD) immobilized membrane was utilized to Organic engine for converting chemical energy of the glucose to mechanical work as pressure changes of consumed oxygen in the GOD catalysis. Characteristic of the pressure changes was in good correlation to the glucose concentrations. Afterward, the drug release unit which utilizes the energy of the Organic engine as a power source was fabricated and evaluated by recording its release actions. The system was then fabricated by combining the both units. As a result of the evaluation test, the system showed the feasibility of autonomous glucose control in closed loop feedback setting as a natural pattern of the insulin secretion on feedback of blood sugar levels.

Original languageEnglish
Title of host publication2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages2426-2429
Number of pages4
DOIs
Publication statusPublished - 1 Sep 2011
Event2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
Duration: 5 Jun 20119 Jun 2011

Publication series

Name2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Conference

Conference2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
CountryChina
CityBeijing
Period5/06/119/06/11

Keywords

  • Energy conversation
  • blood sugar
  • controlling glucose concentration
  • drug release system

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    Arakawa, T., Kato, R., Munkhjargal, M., Takahashi, D., Kudo, H., & Mitsubayashi, K. (2011). A drug-injection system with chemo-mechanical energy conversion for active feedback control of glucose concentration in a blood. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 2426-2429). [5969655] (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). https://doi.org/10.1109/TRANSDUCERS.2011.5969655